{ "checked_date": "2026-10-31", "scope": "ClinicalTrials.gov records for Hemopure/HBOC-201/glutamer-250; not all clinical studies ever conducted", "record_count": 9, "counts_by_study_type": { "INTERVENTIONAL": 6, "EXPANDED_ACCESS": 3 }, "counts_by_status": { "TERMINATED": 1, "UNKNOWN": 2, "COMPLETED": 2, "ENROLLING_BY_INVITATION": 1, "NO_LONGER_AVAILABLE": 3 }, "records": [ { "nct_id": "NCT00300040", "official_title": "Phase II, Multi-Center,Single-Blind,Placebo-Controlled Study,Evaluating Safety & Feasibility of HBOC-201 (Wound Healing Patients With Peripheral Vascular Disease & Undergoing Lower Limb Amputation Due to Critical Lower Limb Ischemia", "protocol_id": "BIOSA001/BIOEU001", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "75 Years", "study_type": "INTERVENTIONAL", "phase": [ "PHASE2" ], "allocation": "RANDOMIZED", "intervention_model": "PARALLEL", "masking": "SINGLE", "status": "TERMINATED", "last_known_status": null, "enrollment_count": 16, "enrollment_type": "ACTUAL", "last_update_posted": "2008-05-16", "status_verified_date": "2008-05", "why_stopped": "Very slow enrollment.Study entry criteria not in line w/local standards of care", "lead_sponsor": "Biopure Corporation", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT00300040", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT00300040", "brief_title": "Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia" }, { "nct_id": "NCT00301483", "official_title": "A Single-Center, Study to Evaluate the Safety and Tolerability of Hemoglobin-Based Oxygen Carrier-201 (HBOC 201) in Trauma Subjects. (Phase II - Safety and Tolerability)", "protocol_id": "HEM-0125", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "65 Years", "study_type": "INTERVENTIONAL", "phase": [ "PHASE2" ], "allocation": "RANDOMIZED", "intervention_model": "CROSSOVER", "masking": "SINGLE", "status": "UNKNOWN", "last_known_status": "RECRUITING", "enrollment_count": 53, "enrollment_type": "ESTIMATED", "last_update_posted": "2008-03-06", "status_verified_date": "2008-02", "why_stopped": null, "lead_sponsor": "Biopure Corporation", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT00301483", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT00301483", "brief_title": "A Single Site Safety and Tolerability Study of HBOC-201 in Trauma Subjects" }, { "nct_id": "NCT00301535", "official_title": "Enhancement of Tissue Preservation During Cardiopulmonary Bypass With HBOC-201 (Registry Study)", "protocol_id": "BIOEU003", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "80 Years", "study_type": "INTERVENTIONAL", "phase": [ "PHASE2" ], "allocation": "NON_RANDOMIZED", "intervention_model": "PARALLEL", "masking": "NONE", "status": "UNKNOWN", "last_known_status": "RECRUITING", "enrollment_count": 60, "enrollment_type": "ESTIMATED", "last_update_posted": "2008-05-16", "status_verified_date": "2008-05", "why_stopped": null, "lead_sponsor": "Biopure Corporation", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT00301535", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT00301535", "brief_title": "A Study of Hemopure® to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery" }, { "nct_id": "NCT00317512", "official_title": "A Multi-Center,Randomized,Double-Blind,Placebo-Controlled,Dose Finding Pilot Study, to Evaluate Safety/Feasibility of HBOC-201 in Elective Percutaneous Coronary Revascularization of Subjects With Acute Coronary Syndromes", "protocol_id": "COR-0001", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "75 Years", "study_type": "INTERVENTIONAL", "phase": [ "PHASE2" ], "allocation": "RANDOMIZED", "intervention_model": "FACTORIAL", "masking": "TRIPLE", "status": "COMPLETED", "last_known_status": null, "enrollment_count": 45, "enrollment_type": "ACTUAL", "last_update_posted": "2008-05-16", "status_verified_date": "2008-05", "why_stopped": null, "lead_sponsor": "Biopure Corporation", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT00317512", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT00317512", "brief_title": "Pilot Study of Hemoglobin Based Oxygen Therapeutics in Elective Coronary Revascularization" }, { "nct_id": "NCT00479895", "official_title": "Phase II, Open-Label Study in the Catheterization Laboratory Setting to Challenge the Concept That HBOC-201 Administration Might Improve Myocardial 'Oxygenation' and Myocardial Function at the Moment of (Brief) Coronary Occlusion", "protocol_id": "COR-0002", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "80 Years", "study_type": "INTERVENTIONAL", "phase": [ "PHASE2" ], "allocation": "RANDOMIZED", "intervention_model": "CROSSOVER", "masking": "SINGLE", "status": "COMPLETED", "last_known_status": null, "enrollment_count": 5, "enrollment_type": "ACTUAL", "last_update_posted": "2008-05-30", "status_verified_date": "2008-05", "why_stopped": null, "lead_sponsor": "Biopure Corporation", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT00479895", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT00479895", "brief_title": "Hemoglobin Based Oxygen Therapeutics in Elective Percutaneous Coronary Revascularization" }, { "nct_id": "NCT01881503", "official_title": "Expanded Access Protocol for the Treatment Use of HBOC-201", "protocol_id": "E-12-454", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "80 Years", "study_type": "INTERVENTIONAL", "phase": [ "NA" ], "allocation": "NA", "intervention_model": "SINGLE_GROUP", "masking": "NONE", "status": "ENROLLING_BY_INVITATION", "last_known_status": null, "enrollment_count": 50, "enrollment_type": "ESTIMATED", "last_update_posted": "2025-04-13", "status_verified_date": "2021-08", "why_stopped": null, "lead_sponsor": "Englewood Hospital and Medical Center", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT01881503", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT01881503", "brief_title": "Expanded Access Study of HBOC-201 (Hemopure) for the Treatment of Life-Threatening Anemia" }, { "nct_id": "NCT02684474", "official_title": "Expanded Access Protocol Using HBOC-201 to Treat Patients With Life Threatening Anemia, for Whom Blood is Not an Option", "protocol_id": "IRB00090805", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "80 Years", "study_type": "EXPANDED_ACCESS", "phase": [], "allocation": null, "intervention_model": null, "masking": null, "status": "NO_LONGER_AVAILABLE", "last_known_status": null, "enrollment_count": null, "enrollment_type": null, "last_update_posted": "2025-10-23", "status_verified_date": "2025-10", "why_stopped": null, "lead_sponsor": "Johns Hopkins University", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT02684474", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT02684474", "brief_title": "Expanded Access Protocol Using HBOC-201" }, { "nct_id": "NCT02934282", "official_title": "Expanded Access Protocol Using HBOC-201", "protocol_id": "20160819", "product": "Hemopure / HBOC-201 / hemoglobin glutamer-250 (bovine)", "participant_species": "Human", "minimum_age": "18 Years", "maximum_age": "80 Years", "study_type": "EXPANDED_ACCESS", "phase": [], "allocation": null, "intervention_model": null, "masking": null, "status": "NO_LONGER_AVAILABLE", "last_known_status": null, "enrollment_count": null, "enrollment_type": null, "last_update_posted": "2024-12-20", "status_verified_date": "2024-12", "why_stopped": null, "lead_sponsor": "Mauricio Lynn", "has_posted_structured_results": false, "official_url": "https://clinicaltrials.gov/study/NCT02934282", "official_api_url": "https://clinicaltrials.gov/api/v2/studies/NCT02934282", "brief_title": "HBOC-201 Expanded Access Protocol for 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"brief_title": "Expanded Access IND Administration of HBOC-201 in Patients With Severe Acute Anemia" } ], "query_audit": [ { "query": "Oxyglobin", "total_count": 0, "official_api_url": "https://clinicaltrials.gov/api/v2/studies?format=json&pageSize=100&countTotal=true&query.term=Oxyglobin", "checked_at": "2026-10-30T21:56:49.464151+00:00", "error": null }, { "query": "\"HBOC-301\"", "total_count": 0, "official_api_url": "https://clinicaltrials.gov/api/v2/studies?format=json&pageSize=100&countTotal=true&query.term=%22HBOC-301%22", "checked_at": "2026-10-30T21:56:49.462732+00:00", "error": null }, { "query": "\"HBOC-200\"", "total_count": 0, "official_api_url": "https://clinicaltrials.gov/api/v2/studies?format=json&pageSize=100&countTotal=true&query.term=%22HBOC-200%22", "checked_at": "2026-10-30T21:56:49.472608+00:00", "error": null }, { "query": "\"hemoglobin glutamer-200\"", "total_count": 0, "official_api_url": 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