{
  "updated": "2026-09-27",
  "scope": "Scientific evidence relevant to BHOC and transplant oxygen delivery. These records are external transplantation studies and are not BHOC efficacy evidence.",
  "records": [
    {
      "id": "TR-REL-2026-001",
      "organ": "Liver",
      "modality": "HOPE / preservation",
      "evidenceType": "Meta-analysis of randomized trials",
      "title": "Hypothermic Oxygenated Perfusion Versus Static Cold Storage in Liver Transplantation: A Meta-Analysis of Randomized Trials",
      "year": 2026,
      "authors": "Ellouze A, Tzedakis S, Zorkot MA, et al.",
      "journal": "Clinical Transplantation",
      "population": "8 randomized trials; 984 adult liver transplant recipients",
      "signal": "HOPE was associated with lower early allograft dysfunction, primary non-function, major complications and biliary complications than static cold storage; one-year graft survival was comparable.",
      "relevance": "Directly relevant to oxygenated preservation, ischemia-reperfusion injury and measurable graft outcomes.",
      "boundary": "Not a BHOC study and does not establish a role for BHOC in perfusion.",
      "doi": "10.1111/ctr.70676",
      "pmid": "42717689",
      "doiUrl": "https://doi.org/10.1111/ctr.70676",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42717689/"
    },
    {
      "id": "TR-REL-2026-002",
      "organ": "Kidney",
      "modality": "Hypothermic machine perfusion",
      "evidenceType": "Single-center retrospective cohort",
      "title": "Machine Perfusion Parameters and 1-Year Outcomes in High KDPI Kidney Transplantation: A Single-Center Cohort Study",
      "year": 2026,
      "authors": "Foster CE, Filardi KFXC, Hanna J, Dar W, Emmanuel B, Morgan G, Serrano OK",
      "journal": "Transplantation Proceedings",
      "population": "71 recipients of kidneys with KDPI ≥85",
      "signal": "Pre-specified machine-perfusion flow and resistance groups did not show statistically significant differences in one-year renal function, graft survival or patient survival.",
      "relevance": "Supports testing whether perfusion measurements are meaningful surrogates for tissue-level benefit and graft function.",
      "boundary": "Observational single-center evidence; not a BHOC or oxygen-carrier study.",
      "doi": "10.1016/j.transproceed.2026.07.036",
      "pmid": "42731909",
      "doiUrl": "https://doi.org/10.1016/j.transproceed.2026.07.036",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42731909/"
    },
    {
      "id": "TR-REL-2026-003",
      "organ": "Lung",
      "modality": "TA-NRP / procurement",
      "evidenceType": "OPTN retrospective analysis",
      "title": "Early-to-Midterm Outcomes of Lung Transplantation Following Procurement with Thoracoabdominal Regional Perfusion: An OPTN Analysis",
      "year": 2026,
      "authors": "O'Neill J, Gregorio PHP, Hassaballa A, et al.",
      "journal": "The Journal of Heart and Lung Transplantation",
      "population": "DCD lung transplantation; 1364 standard rapid recovery and 261 TA-NRP recipients",
      "signal": "One- and three-year survival were comparable. After adjustment, TA-NRP recipients had lower odds of ECMO use at 72 hours.",
      "relevance": "Relevant to regional perfusion, procurement physiology, preservation and oxygen-delivery questions across organs.",
      "boundary": "Registry evidence; not a BHOC or oxygen-carrier study.",
      "doi": "10.1016/j.healun.2026.09.005",
      "pmid": "42731647",
      "doiUrl": "https://doi.org/10.1016/j.healun.2026.09.005",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42731647/"
    },
    {
      "id": "TR-REL-2026-004",
      "organ": "Liver",
      "modality": "HOPE vs NMP",
      "evidenceType": "International real-world cohort",
      "title": "Real-World Analysis of Hypothermic Oxygenated Perfusion and Normothermic Machine Perfusion in Liver Transplantation: An International Cohort Study",
      "year": 2026,
      "authors": "Pfister M, Eden J, Rasel H, et al.",
      "journal": "Annals of Surgery",
      "population": "954 NMP-treated and 1202 HOPE-treated liver grafts",
      "signal": "The study compared contemporary HOPE and NMP practice across international cohorts with substantial baseline donor-risk differences and risk-adjusted analyses.",
      "relevance": "Relevant to how different oxygenated perfusion strategies are selected, measured and compared in real-world transplantation.",
      "boundary": "Non-randomized real-world comparison; not BHOC evidence.",
      "doi": "10.1097/SLA.0000000000007195",
      "pmid": "42684111",
      "doiUrl": "https://doi.org/10.1097/SLA.0000000000007195",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42684111/"
    },
    {
      "id": "TR-REL-2026-005",
      "organ": "Liver",
      "modality": "Normothermic machine perfusion",
      "evidenceType": "Multicenter registry study",
      "title": "Real-World Use of Normothermic Machine Perfusion in Liver Transplantation: A Multi-Institutional Experience From the National Organ Perfusion Registry",
      "year": 2026,
      "authors": "Cortez AR, Loh WS, Sheskey S, et al.",
      "journal": "Clinical Transplantation",
      "population": "545 NMP liver transplants across nine U.S. centers",
      "signal": "The registry described diverse NMP practice and reported a 90-day death-censored graft failure rate of 1.7%.",
      "relevance": "Relevant to deployment, perfusion logistics, viability assessment and outcome measurement in contemporary machine perfusion.",
      "boundary": "Descriptive multicenter registry evidence without a randomized control group; not BHOC evidence.",
      "doi": "10.1111/ctr.70664",
      "pmid": "42672047",
      "doiUrl": "https://doi.org/10.1111/ctr.70664",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42672047/"
    },
    {
      "id": "TR-REL-2022-006",
      "organ": "Kidney",
      "modality": "Gene-edited porcine kidney xenotransplantation",
      "evidenceType": "Two-case human decedent study",
      "title": "Results of Two Cases of Pig-to-Human Kidney Xenotransplantation",
      "year": 2022,
      "publicationDate": "2022-05-19",
      "authors": "Montgomery RA, Stern JM, Lonze BE, et al.",
      "journal": "The New England Journal of Medicine",
      "population": "Two recipients with established brain death; 54-hour observation",
      "signal": "The authors reported urine production and no biopsy evidence of hyperacute or antibody-mediated rejection during the 54-hour observation.",
      "relevance": "External context for the xenograft pathway and early organ-function assessment.",
      "boundary": "Short-term decedent research, not long-term living-recipient evidence. No BHOC or oxygen-carrier intervention was tested.",
      "doi": "10.1056/NEJMoa2120238",
      "pmid": "35584156",
      "doiUrl": "https://doi.org/10.1056/NEJMoa2120238",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/35584156/",
      "briefUrl": "https://bhoctherapeutics.com/evidence/library/transplant/related/montgomery-kidney-xenotransplantation-evidence.html#study-2022",
      "added": "2026-09-27",
      "sourceChecked": "2026-09-27",
      "reviewScope": "Editorial check of original bibliographic record and abstract; not independent verification of underlying data.",
      "classification": "External transplantation research; not BHOC efficacy evidence"
    },
    {
      "id": "TR-REL-2026-007",
      "organ": "Kidney",
      "modality": "Gene-edited porcine kidney xenotransplantation",
      "evidenceType": "Single-recipient human decedent study",
      "title": "Physiology and immunology of a pig-to-human decedent kidney xenotransplant",
      "year": 2026,
      "publicationDate": "2026-02-05",
      "firstOnlineDate": "2025-11-13",
      "authors": "Montgomery RA, Stern JM, Fathi F, Suek N, et al.",
      "journal": "Nature",
      "population": "One recipient with established brain death; planned 61-day observation",
      "signal": "Dialysis independence was achieved. Antibody-mediated rejection developed on day 33; the authors reported reversal after treatment.",
      "relevance": "External context for interpreting graft function alongside immune response in the xenograft pathway.",
      "boundary": "Not 61 rejection-free days. A single decedent study cannot establish long-term living-recipient outcomes or BHOC benefit; no oxygen-carrier intervention was tested.",
      "doi": "10.1038/s41586-025-09847-6",
      "pmid": "41233546",
      "doiUrl": "https://doi.org/10.1038/s41586-025-09847-6",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41233546/",
      "briefUrl": "https://bhoctherapeutics.com/evidence/library/transplant/related/montgomery-kidney-xenotransplantation-evidence.html#study-2026",
      "corrections": [
        {"type": "Publisher Correction", "published": "2026-02-12", "doi": "10.1038/s41586-026-10252-w", "pmid": "41680323", "url": "https://doi.org/10.1038/s41586-026-10252-w"},
        {"type": "Author Correction", "published": "2026-06-04", "doi": "10.1038/s41586-026-10694-2", "pmid": "42243534", "url": "https://doi.org/10.1038/s41586-026-10694-2"}
      ],
      "added": "2026-09-27",
      "sourceChecked": "2026-09-27",
      "reviewScope": "Editorial check of original bibliographic record, abstract and correction trail; no figure-level reanalysis or independent data audit.",
      "classification": "External transplantation research; not BHOC efficacy evidence"
    }
  ],
  "provenance": {
    "sourceRepository": "ArchilJali/BHOC-platform",
    "sourcePath": "transplant/Transplant-relevant-evidence.json",
    "sourceUpdated": "2026-09-19",
    "migrated": "2026-09-26",
    "status": "External transplant context; not BHOC product evidence",
    "migrationScope": "Records TR-REL-2026-001 through TR-REL-2026-005. Later additions carry their own added and sourceChecked dates. Correction notices are linked amendments, not additional study records."
  }
}