01 / Liver
Hypothermic Oxygenated Perfusion Versus Static Cold Storage in Liver Transplantation: A Meta-Analysis of Randomized Trials
- Year:
- 2026
- Design:
- Meta-analysis of randomized trials
- Modality:
- HOPE / preservation
Population / data: 8 randomized trials; 984 adult liver transplant recipients
Published signal: HOPE was associated with lower early allograft dysfunction, primary non-function, major complications and biliary complications than static cold storage; one-year graft survival was comparable.
Limit: HOPE was compared with static cold storage, not with an oxygen-carrier intervention.
DOI: 10.1111/ctr.70676 ↗ · PubMed ↗
02 / Kidney
Machine Perfusion Parameters and 1-Year Outcomes in High KDPI Kidney Transplantation: A Single-Center Cohort Study
- Year:
- 2026
- Design:
- Single-center retrospective cohort
- Modality:
- Hypothermic machine perfusion
Population / data: 71 recipients of kidneys with KDPI ≥85
Published signal: Pre-specified machine-perfusion flow and resistance groups did not show statistically significant differences in one-year renal function, graft survival or patient survival.
Limit: Observational, single-center evidence; no oxygen-carrier intervention was tested.
DOI: 10.1016/j.transproceed.2026.07.036 ↗ · PubMed ↗
03 / Lung
Early-to-Midterm Outcomes of Lung Transplantation Following Procurement with Thoracoabdominal Regional Perfusion: An OPTN Analysis
- Year:
- 2026
- Design:
- OPTN retrospective analysis
- Modality:
- TA-NRP / procurement
Population / data: DCD lung transplantation; 1364 standard rapid recovery and 261 TA-NRP recipients
Published signal: One- and three-year survival were comparable. After adjustment, TA-NRP recipients had lower odds of ECMO use at 72 hours.
Limit: Registry analysis; no oxygen-carrier comparison.
DOI: 10.1016/j.healun.2026.09.005 ↗ · PubMed ↗
04 / Liver
Real-World Analysis of Hypothermic Oxygenated Perfusion and Normothermic Machine Perfusion in Liver Transplantation: An International Cohort Study
- Year:
- 2026
- Design:
- International real-world cohort
- Modality:
- HOPE vs NMP
Population / data: 954 NMP-treated and 1202 HOPE-treated liver grafts
Published signal: The study compared contemporary HOPE and NMP practice across international cohorts with substantial baseline donor-risk differences and risk-adjusted analyses.
Limit: Non-randomized comparison with baseline donor-risk differences.
DOI: 10.1097/SLA.0000000000007195 ↗ · PubMed ↗
05 / Liver
Real-World Use of Normothermic Machine Perfusion in Liver Transplantation: A Multi-Institutional Experience From the National Organ Perfusion Registry
- Year:
- 2026
- Design:
- Multicenter registry study
- Modality:
- Normothermic machine perfusion
Population / data: 545 NMP liver transplants across nine U.S. centers
Published signal: The registry described diverse NMP practice and reported a 90-day death-censored graft failure rate of 1.7%.
Limit: Descriptive registry evidence without a randomized control group.
DOI: 10.1111/ctr.70664 ↗ · PubMed ↗
06 / Kidney
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation
Montgomery RA, Stern JM, Lonze BE, et al. · NEJM · 19 May 2022
- Design:
- Two-case human decedent study
- Observation:
- 54 hours
Published signal: Short-term xenograft function without biopsy signs of hyperacute or antibody-mediated rejection during the observation window.
Limit: Short-term decedent study; it cannot establish outcomes in living recipients.
Read the focused evidence brief →
DOI: 10.1056/NEJMoa2120238 ↗ · PubMed / full author list ↗
07 / Kidney
Physiology and immunology of a pig-to-human decedent kidney xenotransplant
Montgomery RA, Stern JM, Fathi F, Suek N, et al. · Nature · First online 13 November 2025; issue 5 February 2026
- Design:
- Single-recipient human decedent study
- Observation:
- 61 days
Published signal: Dialysis independence; rejection on day 33, reported as reversed after treatment.
Limit: Rejection occurred on day 33; one decedent study cannot establish long-term outcomes in living recipients.
Read the focused evidence brief →
DOI: 10.1038/s41586-025-09847-6 ↗ · PubMed / full author list ↗
Corrections: Publisher, 12 February 2026 · Author, 4 June 2026. Amendments are not counted as separate studies.