Vet Real-World Evidence & Cases for BHOC Veterinary
Veterinary oxygen therapeutics.
Real-world evidence in context.
This is the source-linked veterinary evidence layer supporting the BHOC Veterinary website. It contains publications, documented cases, species evidence, regulatory records and original sources. Scientific interpretation, developing hypotheses and cross-species research questions are kept separately in the BHOC VET-platform.
Evidence architecture: this page is the Evidence Layer. The BHOC VET-platform is the Interpretation & Research Layer, where source-linked evidence is developed into Concepts & Questions without duplicating the underlying evidence library.
The species distribution and catalogue below describe the 236-record preserved base. Search also includes 3 source-verified curated additions (239 active records), without counting existing studies twice.
Browse the bibliography
Species Distribution
Select a species or model group to open matching publications.
Human and in-vitro records provide wider research context; they are not veterinary approvals. Bar lengths compare group counts, not percentages of a whole.
How to interpret these numbers
Counts are records carrying indexed species or model labels, not counts of confirmed treatment studies. A record can appear in several groups; group counts must not be added to obtain the total. Labels may be incomplete.
Exotic / other animals combines ferret, rabbit and other-animal labels, counting each record once. It does not imply wildlife use. Other / In vitro includes in-vitro labels and 13 records with no species label.
Journal names are normalized for the publication filter: known abbreviations and full-name variants are merged, while non-journal or unclassified source labels appear under Other.
Source bibliography · Index methodology
Inside the original FDA record
95% treatment success.
A defined FDA endpoint.
In the FDA efficacy population, treatment success was reported in 20 of 21 Oxyglobin-treated dogs (95%) versus 9 of 28 controls (32%). In the intent-to-treat population, success was 22 of 30 (73%) versus 10 of 34 (29%).
Read the FDA study summary, pp. 4 to 8 ↗- Efficacy population
- 95% / 32%
- Intent-to-treat
- 73% / 29%
- Endpoint window
- 24 hours
Success meant no additional oxygen-carrying support for 24 hours; it was not a survival endpoint. The FDA report also documents adverse reactions, including pulmonary oedema. Results apply to this trial and product, not to every species or a future formulation.
Vet Real-World Evidence & Cases
Documented cases and historical archives
Historical source archive · 885 reports · 146 printed canine vignettes · 1998-1999
What 885 historical Oxyglobin case reports show — and what they do not
A critical review of Oxyglobin Solution - Case Listing Book II: manufacturer-collected reports across blood loss, hemolysis and ineffective erythropoiesis, with treatment-sequence analysis, safety context and explicit evidence limits.
Open the critical archive review →- Reports
- 885
- Printed vignettes
- 146
- Species
- Canine
Descriptive, manufacturer-collected and selection-prone. Not a controlled trial, not a survival estimate and not evidence of BHOC efficacy or use in another species.
Documented real-world case · Working K-9 · catastrophic trauma · Oxyglobin · 22 Aug 2002
K-9 Saxon: Oxyglobin, survival and the legacy of the Saxon Award
Fresno Police K-9 Saxon survived catastrophic line-of-duty injuries after being shot at point-blank range. In a letter reproduced in Biopure's 2002 Annual Report, Fresno Police Chief Jerry Dyer described Oxyglobin as playing a pivotal role in Saxon's survival. Fresno Police later established the Saxon Award in his honor.
Read case & sources →- Case type
- Real-world
- Species
- Canine
- Product
- Oxyglobin
Historical company-published case account supported by an official Fresno Police legacy record; not a controlled clinical trial and not evidence of BHOC efficacy.
Documented real-world case · Evidence K19 · Working K-9 · Penn Vet VHUP · Oxyglobin · Bellwether No. 49 · Spring 2001
Wodan: critical veterinary care, oxygen-carrying support and recovery
Bellwether No. 49 documented Wodan, a five-year-old Belgian Malinois police dog transferred to Penn Vet's VHUP after severe line-of-duty trauma. Oxyglobin was recorded as one component of a broader intensive-care and surgical strategy.
Read case & sources →- Case type
- Real-world
- Species
- Canine
- Product
- Oxyglobin
Historical single-case narrative from a university veterinary publication; documents treatment context and Oxyglobin use but does not establish causality or BHOC efficacy.
Author affiliations are not institutional endorsements and do not identify treatment locations. Historical Oxyglobin approvals do not establish approval of a new BHOC formulation or human use. Documented real-world cases are classified separately from controlled clinical evidence. Section guide · Full citation catalogue.