Peer-reviewed publications and source-linked scientific references relevant to Biological Hemoglobin Oxygen Carriers, HBOC research, oxygen-delivery physiology and Precision Oxygen Therapeutics.
A small feasibility trial examines prophylactic transfusion in pregnancy with Sickle Cell Disease. The study helps separate possible aims of transfusion: reducing HbS, increasing oxygen-carrying capacity and preventing defined maternal or fetal complications.
AABB review showing that restrictive versus liberal RBC transfusion effects vary by clinical context, while shelf life, volume and processing constraints can directly limit RBC availability. The analysis connects these findings with the question of oxygen-delivery function.
PHBTC framework showing how prehospital transfusion decisions are driven by hemorrhagic-shock physiology, with restoration of oxygen delivery before critical ischemia as an explicit goal and time-to-treatment linked to outcome.
Reviews how severe inflammation, endothelial dysfunction, edema and impaired microcirculation can disrupt tissue oxygenation, providing pathophysiological context for Precision Oxygenation Therapeutics and BHOC/HBOC research.
Introduces the L-TOF framework for comparing oxygen-delivery potency and examines how storage age changes the volume of red-cell products required to match fresh blood.
Shows why oxygen-carrying capacity alone cannot define effective oxygen delivery: hemoglobin-linked NO bioactivity, hypoxic vasodilation and microcirculatory blood flow are part of the tissue-oxygenation equation.