Oxygen Diffusion & Microcirculation

Year

2026

DOI

10.1007/978-3-032-22656-3_48

Year

2026

DOI

10.1073/pnas.2537404123

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2026

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2026

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2026

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2026

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2026

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10.1016/j.ajt.2025.12.021

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2026

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Year

2026

Year

2026

DOI

10.3389/fmed.2026.1874098

Authors

Rausch CW, Jaliashvili A

Year

2026

Species / model

Human

Evidence type

Reviews, clinical context & policy

DOI

10.20944/preprints202609.1886.v1

Original citation

Rausch CW, Jaliashvili A. Precision Oxygen Therapeutics: From Blood Substitutes to the Biological Hemoglobin Oxygen Carrier (BHOC) Framework for Controlled Microvascular and Tissue-Level Oxygen Delivery. Preprints.org. 2026. doi:10.20944/preprints202609.1886.v1.

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Year

2026

Authors

Rabcuka J, Fallon J, Meli A, et al.

Journal

Blood Red Cells & Iron

Year

2026

Evidence type

Experimental ex vivo human organ study

DOI

10.1016/j.brci.2025.100038

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Year

2026

DOI

10.1016/j.transci.2026.104443

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42030901

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2026

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2026

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Year

2026

DOI

10.1213/ANE.0000000000007923

PMID

41529673

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Year

2025

DOI

10.1002/dta.3847

Year

2025

DOI

10.1111/ctr.70166

PMID

40294124

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Year

2025

Year

2024

DOI

10.1016/j.jatmed.2024.02.003

Year

2023

DOI

10.1001/jama.2023.12914

Year

2022

DOI

10.1002/JPER.22-0006

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Year

2022

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Year

2022

DOI

10.1146/annurev-physiol-061121-040127

Year

2022

DOI

10.1039/d1lc01058a

PMID

35266475

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Year

2022

Year

2021

PMID

34445250

Year

2021

DOI

10.1016/j.mehy.2020.110421

Year

2021

DOI

10.1001/jama.2021.0135

Year

2021

DOI

10.1152/ajpheart.01021.2020

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Year

2021

Authors

Bodewes SB, van Leeuwen OB, Thorne AM, et al

Journal

International Journal of Molecular Sciences

Year

2021

Evidence type

Unclear - verify full text

DOI

10.3390/ijms22010235

Original citation

Bodewes SB, van Leeuwen OB, Thorne AM, et al. International Journal of Molecular Sciences. 2021; 22(1):235.

Year

2021

PMID

33881456

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2021

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2020

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Year

2020

DOI

10.1172/JCI137554

Year

2020

PMID

32010773

Authors

Stankiewicz J, Jeyaraju M, Maheshwari S, et al

Journal

In A44

Year

2020

Evidence type

Human clinical evidence

DOI

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1721

Original citation

Stankiewicz J, Jeyaraju M, Maheshwari S, et al. In A44. CRITICAL CARE CASE REPORTS: HEMATOLOGY AND ONCOLOGY 2020 May (pp. A1721-A1721). American Thoracic Society.

Year

2020

DOI

10.1111/ajt.15798

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Sahu A, Kwon I, Tae G

Journal

Biomaterials

Year

2020

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2020

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Stride E, Segers T, Lajoinie G, Cherkaoui S, Bettinger T, Versluis M, Borden M

Year

2020

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2020

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Year

2020

DOI

10.1016/j.transci.2020.103016

Year

2020

DOI

10.1016/j.coph.2020.09.009

Year

2020

DOI

10.1016/S0140-6736(20)32411-9

PMID

33220737

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Authors

Kooiman K, Roovers S, Langeveld SAG, Kleven RT, Dewitte H, O’Reilly MA, Escoffre J-M, Bouakaz A, Verweij MD, Hynynen K, et al.

Year

2020

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Authors

Yang G, Tian J, Chen C, Jiang D, Xue Y, Wang C, Gao Y, Zhang W

Year

2019

Year

2019

DOI

10.1111/jcmm.14666

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Xing L, Gong J-H, Wang Y, Zhu Y, Huang Z-J, Zhao J, Li F, Wang J-H, Wen H, Jiang H-L

Journal

Biomaterials

Year

2019

Year

2019

PMID

31562027

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2019

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2019

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Song D, Beringhs AOR, Zhuang Z, Joshi G, T. Huyen Tran, Claffey KP, Yuan H, Lu X

Journal

Nanotheranostics

Year

2019

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Feng L, Betzer O, Tao D, Sadan T, Popovtzer R, Liu Z

Year

2019

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Zhou J, Xue C, Hou Y, Li M, Hu Y, Chen Q, Li Y, Li K, Song G, Cai K, et al.

Journal

Biomaterials

Year

2019

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Zhou Z, Zhang B, Zai W, Kang L, Yuan A, Hu Y, Wu J

Journal

USA

Year

2019

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2019

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Logan K, Foglietta F, Nesbitt H, Sheng Y, McKaig T, Kamila S, Gao J, Nomikou N, Callan B, McHale AP, et al.

Year

2019

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2019

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Authors

Li J, Shang W, Li Y, Fu S, Tian J, Lu L

Year

2018

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Lu N, Fan W, Yi X, Wang S, Wang Z, Tian R, Jacobson O, Liu Y, Yung BC, Zhang G, et al.

Journal

ACS Nano

Year

2018

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Bose RJC, Paulmurugan R, Moon J, Lee S-H, Park H

Journal

Today

Year

2018

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Wang Q, Li J-M, Yu H, Deng K, Zhou W, Wang C-X, Zhang Y, Li KH, Zhuo R-X, Huang S-W

Year

2018

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2018

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Li Y, Patel SP, Roszik J, Qin Y

Year

2018

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Chong WK, Papadopoulou V, Dayton PA

Year

2018

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Yang C, Xiao H, Sun Y, Zhu L, Gao Y, Kwok S, Wang Z, Tang Y

Year

2018

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Year

2018

DOI

10.1111/trf.14488

PMID

29383722

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Graham K, Unger E

Year

2018

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2018

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2018

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Authors

Zhou Z, Zhang B, Wang H, Yuan A, Hu Y, Wu J

Journal

Theranostics

Year

2018

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Year

2017

Year

2017

PMID

28129479

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Year

2017

DOI

10.1146/annurev-fluid-010816-060302

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Authors

Gao M, Liang C, Song X, Q.Chen, Jin Q, Wang C, Liu Z

Year

2017

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Day RA, Estabrook DA, Logan JK, Sletten EM

Year

2017

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Year

2017

Authors

Salmen M, Hendriksen S, Gorlin J, LeClaire M, Prekker ME

Journal

Ann Am Thorac Soc

Year

2017

Evidence type

Pending full-text classification

DOI

10.1513/annalsats.201612-1039cc

PMID

28665709

Original citation

Salmen M, Hendriksen S, Gorlin J, LeClaire M, Prekker ME. Oxygen Delivery during Severe Anemia When Blood Transfusion Is Refused on Religious Grounds. Ann Am Thorac Soc. 2017 Jul;14(7):1216-1220. doi: 10.1513/AnnalsATS.201612-1039CC. PubMed PMID: 28665709.

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Ren H, Liu J, Li Y, Wang H, Ge S, Yuan A, Hu Y, Wu J

Year

2017

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Chen J, Luo H, Liu Y, Zhang W, Li H, Luo T, Zhang K, Zhao Y, Liu J

Journal

ACS Nano

Year

2017

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2017

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Authors

Ren H, Liu J, Su F, Ge S, Yuan A, Dai W, Wu J, Hu Y

Journal

Interfaces

Year

2017

Year

2017

DOI

10.1056/NEJMoa1711818

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Authors

Song G, Ji C, Liang C, Song X, Yi X, Dong Z, Yang K, Liu Z

Journal

Biomaterials

Year

2017

Year

2017

PMID

29223560

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Authors

Hatfield SM, Sitkovsky M

Year

2016

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Authors

Restifo NP, Smyth MJ, Snyder A

Journal

Cancer

Year

2016

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Authors

McEwan C, Kamila S, Owen J, Nesbitt H, Callan B, Borden M, Nomikou N, Hamoudi RA, Taylor MA, Stride E, et al.

Journal

Biomaterials

Year

2016

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Whiteside TL, Demaria S, Rodriguez-Ruiz ME, Zarour HM, Melero I

Year

2016

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Que Y, Liu Y, Tan W, Feng C, Shi P, Li Y, Huang X

Year

2016

Year

2016

DOI

10.1111/vaa.12258

PMID

25818866

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Song G, Liang C, Yi X, Zhao Q, Cheng L, Yang K, Liu Z

Year

2016

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Zhou Z, Song J, Nie L, Chen X

Year

2016

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McHale AP, Callan JF, Nomikou N, Fowley C, Callan B

Journal

Edited by Escoffre J-M, Bouakaz A: Springer Switzerland;

Year

2016

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Song X, Feng L, Liang C, Yang K, Liu Z

Year

2016

Year

2016

PMID

26661200

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Authors

Hatfield SM, Kjaergaard J, Lukashev D, Schreiber TH, Belikoff B, Abbott R, Sethumadhavan S, Philbrook P, Ko K, Cannici R, et al.

Year

2015

Year

2015

DOI

10.1056/NEJMoa1403612

Authors

Picot J, Ndour PA, Lefevre SD, et al.

Journal

American Journal of Hematology

Year

2015

DOI

10.1002/ajh.23941

PMID

25641515

Original citation

Picot J, Ndour PA, Lefevre SD, et al. A biomimetic microfluidic chip to study the circulation and mechanical retention of red blood cells in the spleen. American Journal of Hematology. 2015;90(4):339–345.

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Authors

Cheng Y, Cheng H, Jiang C, Qiu X, Wang K, W.Huan, Yuan A, Wu J, Hu Y

Year

2015

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Authors

Johnson JLH, Leos RA, Baker AF, Unger EC

Year

2015

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Authors

Schmieder AH, Caruthers SD, Keupp J, Wickline SA, Lanza GM

Journal

Engineering (Beijing)

Year

2015

Year

2015

PMID

26119027

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Year

2015

PMID

25986133

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Authors

Huang W-C, Chiang W-H, Cheng Y-H, Lin W-C, Yu C-F, Yen C-Y, Yeh C-K, Chern C-S, Chiang C-S, Chiu H-C

Journal

Biomaterials

Year

2015

Year

2014

DOI

10.1063/1.4895755

PMID

25332724

Year

2014

PMID

24670647

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2014

Year

2014

PMID

24370245

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Authors

Sitkovsky MV, Hatfield S, Abbott R, Belikoff B, Lukashev D, Ohta A

Year

2014

Authors

Peruski AM, Cooper ES, Butler AL

Journal

American Journal of Veterinary Research

Year

2014

Evidence type

Veterinary clinical / research

DOI

10.2460/ajvr.75.1.77

PMID

24370249

Original citation

Microcirculatory effects of a hyperviscous hemoglobin-based solution administered intravenously in dogs with experimentally induced hemorrhagic shock. Peruski AM, Cooper ES, Butler AL. Am J Vet Res. 2014 Jan;75(1):77-84. doi: 10.2460/ajvr.75.1.77. PMID: 24370249 [PubMed - indexed for MEDLINE] Similar articles

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2014

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Authors

Ahrens ET, Bulte JWM

Year

2013

Year

2013

PMID

22981700

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Year

2012

PMID

22293984

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Authors

Sheeran PS, Luois S, Mullin L, Matsunaga TO, Dayton PA

Journal

Biomaterials

Year

2012

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2012

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2012

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2012

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Authors

Liu H-L, Hsieh H-Y, Lu L-A, Kang C-W, Wu M-F, Lin C-Y

Year

2012

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Authors

Maillard E, Juszczak MT, Langlois A, Kleiss C, Sencier MC, Bietiger W, Dominguez MS, Krafft MP, Johnson PRV, Pinget M, et al.

Year

2012

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Authors

Meijer TWH, Kaanders JHAM, Span PN, Bussink J

Year

2012

Year

2012

DOI

10.1038/jcbfm.2011.153

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Authors

Kwan JJ, Kaya M, Borden MA, Dayton PA

Journal

Theranostics

Year

2012

Authors

Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK, Rosenfeld JV

Journal

Med J Aust

Year

2011

Evidence type

Pending full-text classification

PMID

21534906

Original citation

A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Fitzgerald MC, Chan JY, Ross AW, Liew SM, Butt WW, Baguley D, Salem HH, Russ MK, Deasy C, Martin KE, Mathew JK, Rosenfeld JV. Med J Aust. 2011 May 2;194(9):471-3. PMID: 21534906 [PubMed - indexed for MEDLINE] Similar articles

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Year

2011

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Authors

Rohwer N, Cramer T

Journal

Update

Year

2011

Year

2011

PMID

21281453

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Year

2011

DOI

10.1111/j.1600-6143.2011.03614.x

PMID

21875432

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Authors

Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang L-P, Gimotty PA, Gilks CB, P.Lal, Zhang L, et al.

Journal

Nature

Year

2011

Authors

Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, et al.

Journal

American Journal of Respiratory Cell and Molecular Biology

Year

2010

Species / model

Rodent

Author institutions

University of Colorado

Evidence type

In vitro / analytical

DOI

10.1165/rcmb.2008-0364oc

PMID

19395680

Original citation

Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, et al. Mixed S-Nitrosylated Polymerized Bovine Hemoglobin Species Moderate Hemodynamic Effects in Acutely Hypoxic Rats. American Journal of Respiratory Cell and Molecular Biology. 2010;42(2):200-9.

Authors

Borland CD, Dunningham H, Bottrill F, Vuylsteke A, Yilmaz C, Dane DM, Hsia CC

Journal

Journal of Applied Physiology

Year

2010

Evidence type

Unclear — verify full text

DOI

10.1152/japplphysiol.00904.2009

PMID

20150569

Original citation

Significant blood resistance to nitric oxide transfer in the lung. Borland CD, Dunningham H, Bottrill F, Vuylsteke A, Yilmaz C, Dane DM, Hsia CC. J Appl Physiol (1985). 2010 May;108(5):1052-60. doi: 10.1152/japplphysiol.00904.2009. Epub 2010 Feb 11. PMID: 20150569 [PubMed - indexed for MEDLINE] Free PMC Article Similar articles

Year

2010

PMID

20119709

Original identifier requires bibliographic review

Authors

Yu B, Bloch KD, Zapol WM

Journal

Trends Cardiovasc Med

Year

2009

Evidence type

Unclear — verify full text

DOI

10.1016/j.tcm.2009.06.004

PMID

19679268

Original citation

Hemoglobin-based red blood cell substitutes and nitric oxide. Yu B, Bloch KD, Zapol WM. Trends Cardiovasc Med. 2009 Apr;19(3):103-7. doi: 10.1016/j.tcm.2009.06.004. PMID: 19679268 [PubMed - indexed for MEDLINE] Free PMC Article Similar articles

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Authors

Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT

Year

2009

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Year

2009

Authors

Manalo DJ, Buehler PW, Baek JH, Butt O, D'agnillo F, Alayash AI

Journal

Biochem J

Year

2008

Evidence type

Preclinical evidence supporting human development

DOI

10.1042/bj20080313

PMID

18498252

Original citation

Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats. Manalo DJ, Buehler PW, Baek JH, Butt O, D'agnillo F, Alayash AI. Biochem J. 2008 Sep 15;414(3):461-9. doi: 10.1042/BJ20080313. PMID: 18498252 [PubMed - indexed for MEDLINE] Similar articles

Authors

Gundersen SI, Palmer AF

Journal

Biotechnol Prog

Year

2008

Evidence type

Preclinical evidence supporting human development

DOI

10.1002/btpr.56

PMID

19194950

Original citation

Hemoglobin-based oxygen carrier enhanced tumor oxygenation: a novel strategy for cancer therapy. Gundersen SI, Palmer AF. Biotechnol Prog. 2008 Nov-Dec;24(6):1353-64. doi: 10.1002/btpr.56. PMID: 19194950 [PubMed - indexed for MEDLINE] Similar articles

Research direction

Capillary oxygen transport models; P50, oxygen affinity and cooperativity; Microcirculation, low hematocrit and tissue hypoxia

Year

2008

DOI

10.1056/NEJMoa0802289

Authors

Irwin DC, Foreman B, Morris K, White M, Sullivan T, Jacobs R, et al.

Journal

American Journal of Physiology

Year

2008

Species / model

Rodent

Author institutions

University of Colorado

Evidence type

In vitro / analytical

DOI

10.1152/ajpheart.00303.2008

PMID

18567708

Original citation

Irwin DC, Foreman B, Morris K, White M, Sullivan T, Jacobs R, et al. Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. American Journal of Physiology-Heart and Circulatory Physiology. 2008;295(3).

Year

2008

DOI

10.1182/blood-2008-01-115261

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Authors

Choi MR, Stanton-Maxey KJ, Stanley JK, Levin CS, Bardhan R, Akin D, al. e

Year

2007

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Year

2007

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Year

2007

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Year

2007

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Year

2007

PMID

18077341

Original identifier requires bibliographic review

Year

2007

DOI

10.1146/annurev.bioeng.9.060906.151959

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Year

2006

Original identifier requires bibliographic review

Authors

Stollings JL, Oyen LJ

Journal

Pharmacotherapy

Year

2006

Species / model

Human

Author institutions

Mayo Clinic

Evidence type

Reviews, clinical context & policy

DOI

10.1592/phco.26.10.1453

PMID

16999656

Original citation

Oxygen therapeutics: oxygen delivery without blood. Stollings JL, Oyen LJ. Pharmacotherapy. 2006 Oct;26(10):1453-64. Review. PMID: 16999656 [PubMed - indexed for MEDLINE] Similar articles

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Authors

Sanchez-Dominguez M, Krafft MP, Maillard E, Siegrist S, Belcourt A

Journal

ChemBioChem

Year

2006

Year

2005

DOI

10.1081/BIO-200046654

Year

2005

PMID

16086785

Original identifier requires bibliographic review

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Year

2005

Original identifier requires bibliographic review

Authors

Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, Freitag M, Standl T, Bloechle C, Izbicki JR

Journal

Pancreas

Year

2005

Species / model

Rodent

Author institutions

University Medical Center Hamburg-Eppendorf

Evidence type

Journal Article

DOI

10.1097/01.mpa.0000157481.22155.2d

PMID

15782104

Original citation

Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis. Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, Freitag M, Standl T, Bloechle C, Izbicki JR. Pancreas. 2005 Apr;30(3):254-9. PMID: 15782104 [PubMed - indexed for MEDLINE] Similar articles

Year

2005

PMID

15804974

Original identifier requires bibliographic review

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Year

2005

Year

2004

PMID

15210452

Original identifier requires bibliographic review

Year

2004

PMID

15548898

Original identifier requires bibliographic review

Year

2004

PMID

15191895

Original identifier requires bibliographic review

Year

2003

PMID

14638939

Original identifier requires bibliographic review

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Authors

Schutt ES, Klein DH, Mattrey RM, Riess JG

Year

2003

Year

2003

PMID

14561680

Original identifier requires bibliographic review

Year

2003

PMID

12805029

Original identifier requires bibliographic review

Year

2003

DOI

10.1038/nm954

PMID

14595407

Year

2003

PMID

12843412

Original identifier requires bibliographic review

Year

2003

PMID

12842813

Original identifier requires bibliographic review

Year

2003

PMID

12794426

Original identifier requires bibliographic review

Year

2003

PMID

12805024

Original identifier requires bibliographic review

Authors

Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT

Journal

Journal of Trauma

Year

2003

Evidence type

Pending full-text classification

PMID

12579047

Original citation

Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC- 201. Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT. J Trauma. 2003 Feb;54(2):242-52. PMID: 12579047 [PubMed - indexed for MEDLINE] Similar articles

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Year

2002

Authors

Kavdia M, Tsoukias NM, Popel AS

Journal

American Journal of Physiology

Year

2002

Species / model

In vitro / laboratory

Author institutions

Johns Hopkins University

Evidence type

In vitro / analytical

DOI

10.1152/ajpheart.00972.2001

PMID

12003834

Original citation

Kavdia M, Tsoukias NM, Popel AS. Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes. American Journal of Physiology-Heart and Circulatory Physiology. 2002;282(6).

Authors

Tsai AG, Intaglietta M

Journal

The Keio Journal of Medicine

Year

2002

Species / model

Human

Author institutions

University of California, San Diego

Evidence type

Research Support, U.S. Gov't, P.H.S.; Journal Article

DOI

10.2302/kjm.51.17

PMID

11951374

Original citation

Tsai AG, Intaglietta M. The unusual properties of effective blood substitutes. The Keio Journal of Medicine. 2002;51(1):17–20.

Original identifier requires bibliographic review

Authors

Kavdia M, Pittman RN, Popel AS

Journal

Journal of Applied Physiology

Year

2002

Species / model

Feline (Cat), Human, In vitro / laboratory

Author institutions

Johns Hopkins University

Evidence type

In vitro / analytical

DOI

10.1152/japplphysiol.00676.2002

PMID

12391075

Original citation

Kavdia M, Pittman RN, Popel AS. Theoretical analysis of effects of blood substitute affinity and cooperativity on organ oxygen transport. Journal of Applied Physiology. 2002;93(6):2122-8.

Research direction

Capillary oxygen transport models; P50, oxygen affinity and cooperativity; Oxygen distribution and vascular effects

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Authors

Spahn DR, Waschke KF, Standl T, Motsch J, Van Huynegem L, Welte M, Gombotz H, Coriat P, Verkh L, Faithfull S, et al.

Journal

Anesthesiology

Year

2002

Year

2001

DOI

10.1126/science.1059817

PMID

11292862

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Year

2001

Year

2001

DOI

10.1126/science.1059796

PMID

11292861

Year

2000

DOI

10.2746/042516400777611973

PMID

10661387

Year

1999

DOI

10.1056/NEJM199902113400601

Bibliographic details require source verification.

Year

1998

Year

1997

DOI

10.1126/science.276.5321.2034

PMID

9197264

Year

1996

PMID

8873492

Original identifier requires bibliographic review

Year

1995

DOI

10.1073/pnas.92.12.5510

PMID

7539918

Year

1995

DOI

10.1074/jbc.270.3.1230

PMID

7836384

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Authors

Teicher BA, Holden SA, Ara G, Dupuis NP, Goff D

Year

1995

Year

1995

DOI

10.1152/ajpheart.1995.269.6.H2155

PMID

8594927

Year

1992

DOI

10.1128/mcb.12.12.5447-5454.1992

PMID

1448077

Year

1990

PMID

2134638

Original identifier requires bibliographic review

Year

1990

PMID

2293502

Bibliographic details require source verification.

Year

1989

PMID

2645852

Replaced an imported search-query link with the exact PubMed record after matching the publication title and year on 11 October 2026.

Year

1987

DOI

10.1038/327524a0

PMID

3495737

Year

1985

DOI

10.1016/0026-2862(85)90050-0

PMID

4046869

Year

1982

PMID

6289053

Original identifier requires bibliographic review

Year

1981

PMID

7282939

Original identifier requires bibliographic review

Citation record. A verified article link or abstract is not currently available.

Bibliographic details require source verification.

Year

1980

Year

1980

PMID

7361909

Original identifier requires bibliographic review

Year

1980

PMID

6996587

Original identifier requires bibliographic review

Year

1980

PMID

6108531

Original identifier requires bibliographic review

Year

1980

DOI

10.1038/288373a0

PMID

6253831

Year

1973

PMID

4500075

Original identifier requires bibliographic review

Year

1950

PMID

14783837

Original identifier requires bibliographic review

Bibliographic details require source verification.

Year

1931

Year

1928

DOI

10.1098/rspb.1928.0064

Bibliographic details require source verification.

Year

1920

Year

1919

PMID

16993405

Original identifier requires bibliographic review

Year

1919

PMID

16993410

Original identifier requires bibliographic review

Historical physiology study of the influence of carbon dioxide tension on oxygen binding in blood, published in 1904 by Bohr, Hasselbalch and Krogh.

Authors

Bohr C, Hasselbalch K, Krogh A

Journal

Skandinavisches Archiv für Physiologie

Year

1904

DOI

10.1111/j.1748-1716.1904.tb01382.x

Original citation

Bohr C, Hasselbalch K, Krogh A. Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt. Skandinavisches Archiv für Physiologie. 1904;16(2):402–412.

The imported English title is a descriptive label. The original German title, authors, journal, year, volume and pages were checked against the Wiley publication record on 11 October 2026.

Authors

Thomas Parker; David Brealey; Alex Dyson; Mervyn Singer

Journal

British Journal of Anaesthesia

Year

2019

Author institutions

UCL

Evidence type

Tissue oxygenation / perfusion

DOI

10.1016/j.bja.2019.03.027

PMID

31054772

Original citation

Thomas Parker; David Brealey; Alex Dyson; Mervyn Singer. Optimising organ perfusion in the high-risk surgical and critical care patient: a narrative review. British Journal of Anaesthesia. 2019;123(2):170-176. doi:10.1016/j.bja.2019.03.027. PMID:31054772.

Scientific context relevant to tissue oxygenation and microcirculation; not evidence of BHOC efficacy.

Authors

Alex Dyson; Ray Stidwill; Val Taylor; Mervyn Singer

Journal

American Journal of Physiology Heart and Circulatory Physiology

Year

2007

Author institutions

UCL

Evidence type

Tissue oxygenation / perfusion

DOI

10.1152/ajpheart.00052.2007

PMID

17384135

Original citation

Alex Dyson; Ray Stidwill; Val Taylor; Mervyn Singer. Tissue oxygen monitoring in rodent models of shock. American Journal of Physiology Heart and Circulatory Physiology. 2007;293(1):H526-H533. doi:10.1152/ajpheart.00052.2007. PMID:17384135.

Scientific context relevant to tissue oxygenation and microcirculation; not evidence of BHOC efficacy.

Authors

Nasirul J Ekbal; Alex Dyson; Claire Black; Mervyn Singer

Journal

Chest

Year

2013

Author institutions

UCL

Evidence type

Tissue oxygenation / perfusion

DOI

10.1378/chest.12-1849

PMID

23732592

Original citation

Nasirul J Ekbal; Alex Dyson; Claire Black; Mervyn Singer. Monitoring tissue perfusion, oxygenation, and metabolism in critically ill patients. Chest. 2013;143(6):1799-1808. doi:10.1378/chest.12-1849. PMID:23732592.

Scientific context relevant to tissue oxygenation and microcirculation; not evidence of BHOC efficacy.

Authors

Alex Dyson; Ray Stidwill; Val Taylor; Mervyn Singer

Journal

Intensive Care Medicine

Year

2009

Author institutions

UCL

Evidence type

Tissue oxygenation / perfusion

DOI

10.1007/s00134-009-1577-2

PMID

19618165

Original citation

Alex Dyson; Ray Stidwill; Val Taylor; Mervyn Singer. The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage. Intensive Care Medicine. 2009;35(10):1783-1791. doi:10.1007/s00134-009-1577-2. PMID:19618165.

Scientific context relevant to tissue oxygenation and microcirculation; not evidence of BHOC efficacy.

Authors

Alex Dyson; Alain Rudiger; Mervyn Singer

Journal

Intensive Care Medicine

Year

2011

Author institutions

UCL

Evidence type

Tissue oxygenation / perfusion

DOI

10.1007/s00134-011-2227-z

PMID

21533572

Original citation

Alex Dyson; Alain Rudiger; Mervyn Singer. Temporal changes in tissue cardiorespiratory function during faecal peritonitis. Intensive Care Medicine. 2011;37(7):1192-1200. doi:10.1007/s00134-011-2227-z. PMID:21533572.

Scientific context relevant to tissue oxygenation and microcirculation; not evidence of BHOC efficacy.

Authors

T C Page; W R Light; C B McKay; J D Hellums

Journal

Microvascular Research

Year

1998

Species / model

In vitro / laboratory

Author institutions

Rice University

Evidence type

In vitro experimental study

DOI

10.1006/mvre.1997.2055

PMID

9473409

Original citation

T C Page; W R Light; C B McKay; J D Hellums. Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance. Microvascular Research. 1998;55(1):54-64. doi:10.1006/mvre.1997.2055. PMID:9473409.

Research direction

RBC and extracellular hemoglobin comparisons; Facilitated diffusion and transport resistance

Authors

T C Page; W R Light; J D Hellums

Journal

Microvascular Research

Year

1998

Species / model

In silico / modelling

Author institutions

Biopure Corporation

Evidence type

Computational model

DOI

10.1006/mvre.1998.2088

PMID

9756734

Original citation

T C Page; W R Light; J D Hellums. Prediction of microcirculatory oxygen transport by erythrocyte/hemoglobin solution mixtures. Microvascular Research. 1998;56(2):113-126. doi:10.1006/mvre.1998.2088. PMID:9756734.

Research direction

Capillary oxygen transport models; RBC and extracellular hemoglobin comparisons

Authors

M R McCarthy; K D Vandegriff; R M Winslow

Journal

Biophysical Chemistry

Year

2001

Species / model

In silico / modelling

Author institutions

University of California San Diego

Evidence type

Computational model

DOI

10.1016/s0301-4622(01)00194-6

PMID

11527583

Original citation

M R McCarthy; K D Vandegriff; R M Winslow. The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers. Biophysical Chemistry. 2001;92(1-2):103-117. doi:10.1016/s0301-4622(01)00194-6. PMID:11527583.

Research direction

RBC and extracellular hemoglobin comparisons; Facilitated diffusion and transport resistance

Authors

Arjun Vadapalli; Daniel Goldman; Aleksander S Popel

Journal

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Year

2002

Species / model

In silico / modelling

Author institutions

Johns Hopkins University

Evidence type

Computational model

DOI

10.1081/bio-120004338

PMID

12066873

Original citation

Arjun Vadapalli; Daniel Goldman; Aleksander S Popel. Calculations of oxygen transport by red blood cells and hemoglobin solutions in capillaries. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 2002;30(3):157-188. doi:10.1081/bio-120004338. PMID:12066873.

Research direction

Capillary oxygen transport models; RBC and extracellular hemoglobin comparisons; P50, oxygen affinity and cooperativity; Facilitated diffusion and transport resistance

Authors

Jaqunda N Patton; Andre F Palmer

Journal

Biotechnology Progress

Year

2006

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1021/bp060022a

PMID

16889379

Original citation

Jaqunda N Patton; Andre F Palmer. Numerical simulation of oxygen delivery to muscle tissue in the presence of hemoglobin-based oxygen carriers. Biotechnology Progress. 2006;22(4):1025-1049. doi:10.1021/bp060022a. PMID:16889379.

Research direction

Capillary oxygen transport models; Microcirculation, low hematocrit and tissue hypoxia

Authors

Nikolaos M Tsoukias; Daniel Goldman; Arjun Vadapalli; Roland N Pittman; Aleksander S Popel

Journal

Journal of Theoretical Biology

Year

2007

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1016/j.jtbi.2007.06.012

PMID

17686494

Original citation

Nikolaos M Tsoukias; Daniel Goldman; Arjun Vadapalli; Roland N Pittman; Aleksander S Popel. A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks. Journal of Theoretical Biology. 2007;248(4):657-674. doi:10.1016/j.jtbi.2007.06.012. PMID:17686494.

Research direction

Capillary oxygen transport models; Microcirculation, low hematocrit and tissue hypoxia; Oxygen distribution and vascular effects

Authors

Russell H Cole; Kim D Vandegriff; Andrew J Szeri; Omer Savaş; Dale A Baker; Robert M Winslow

Journal

Biophysical Chemistry

Year

2007

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1016/j.bpc.2007.03.004

PMID

17418478

Original citation

Russell H Cole; Kim D Vandegriff; Andrew J Szeri; Omer Savaş; Dale A Baker; Robert M Winslow. A quantitative framework for the design of acellular hemoglobins as blood substitutes: implications of dynamic flow conditions. Biophysical Chemistry. 2007;128(1):63-74. doi:10.1016/j.bpc.2007.03.004. PMID:17418478.

Research direction

Capillary oxygen transport models; P50, oxygen affinity and cooperativity; Facilitated diffusion and transport resistance

Authors

Russell Cole; Kim Vandegriff; Andrew Szeri; Omer Savas; Robert Winslow

Journal

Microvascular Research

Year

2008

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1016/j.mvr.2008.07.002

PMID

18671987

Original citation

Russell Cole; Kim Vandegriff; Andrew Szeri; Omer Savas; Robert Winslow. Targeted O2 delivery by blood substitutes: in vitro arteriolar simulations of first- and second-generation products. Microvascular Research. 2008;76(3):169-179. doi:10.1016/j.mvr.2008.07.002. PMID:18671987.

Research direction

RBC and extracellular hemoglobin comparisons; P50, oxygen affinity and cooperativity; Oxygen distribution and vascular effects

Authors

F Kreuzer; L J Hoofd

Journal

Respiration Physiology

Year

1970

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1016/0034-5687(70)90037-x

PMID

5434415

Original citation

F Kreuzer; L J Hoofd. Facilitated diffusion of oxygen in the presence of hemoglobin. Respiration Physiology. 1970;8(3):280-302. doi:10.1016/0034-5687(70)90037-x. PMID:5434415.

Research direction

Facilitated diffusion and transport resistance

Authors

J A Jacquez; H Kutchai; E Daniels

Journal

Respiration Physiology

Year

1972

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1016/0034-5687(72)90096-5

PMID

5042165

Original citation

J A Jacquez; H Kutchai; E Daniels. Hemoglobin-facilitated diffusion of oxygen: interfacial and thickness effects. Respiration Physiology. 1972;15(2):166-181. doi:10.1016/0034-5687(72)90096-5. PMID:5042165.

Research direction

Facilitated diffusion and transport resistance

Authors

S I Rubinow; M Dembo

Journal

Biophysical Journal

Year

1977

Species / model

In silico / modelling

Evidence type

Computational model

DOI

10.1016/S0006-3495(77)85594-X

PMID

856316

Original citation

S I Rubinow; M Dembo. The facilitated diffusion of oxygen by hemoglobin and myoglobin. Biophysical Journal. 1977;18(1):29-42. doi:10.1016/S0006-3495(77)85594-X. PMID:856316.

Research direction

Facilitated diffusion and transport resistance

Authors

E J Boland; P K Nair; D D Lemon; J S Olson; J D Hellums

Journal

Journal of Applied Physiology

Year

1987

Species / model

In vitro / laboratory

Evidence type

In vitro experimental study

DOI

10.1152/jappl.1987.62.2.791

PMID

3558238

Original citation

E J Boland; P K Nair; D D Lemon; J S Olson; J D Hellums. An in vitro capillary system for studies on microcirculatory O2 transport. Journal of Applied Physiology. 1987;62(2):791-797. doi:10.1152/jappl.1987.62.2.791. PMID:3558238.

Research direction

RBC and extracellular hemoglobin comparisons; Facilitated diffusion and transport resistance

Authors

C Hook; K Yamaguchi; P Scheid; J Piiper

Journal

Respiration Physiology

Year

1988

Species / model

In vitro / laboratory

Evidence type

In vitro experimental study

DOI

10.1016/0034-5687(88)90080-1

PMID

3363237

Original citation

C Hook; K Yamaguchi; P Scheid; J Piiper. Oxygen transfer of red blood cells: experimental data and model analysis. Respiration Physiology. 1988;72(1):65-82. doi:10.1016/0034-5687(88)90080-1. PMID:3363237.

Research direction

RBC and extracellular hemoglobin comparisons; Facilitated diffusion and transport resistance

Authors

A S Popel

Journal

Critical Reviews in Biomedical Engineering

Year

1989

Author institutions

Johns Hopkins University

Evidence type

Review

PMID

2673661

Original citation

A S Popel. Theory of oxygen transport to tissue. Critical Reviews in Biomedical Engineering. 1989;17(3):257-321. PMID:2673661.

Research direction

Capillary oxygen transport models; Facilitated diffusion and transport resistance; Microcirculation, low hematocrit and tissue hypoxia

DOI not confirmed in the checked bibliographic sources; use the verified PubMed record.

Authors

M Hashimoto; R Hata; T Shiga; A Isomoto; M Uozumi

Journal

Advances in Experimental Medicine and Biology

Year

1990

Species / model

In vitro / laboratory

Author institutions

Osaka University

Evidence type

In vitro experimental study

DOI

10.1007/978-1-4684-8181-5_23

PMID

2096624

Original citation

M Hashimoto; R Hata; T Shiga; A Isomoto; M Uozumi. Facilitated transport of oxygen through hemoglobin solutions. Advances in Experimental Medicine and Biology. 1990;277:181-190. doi:10.1007/978-1-4684-8181-5_23. PMID:2096624.

Research direction

Facilitated diffusion and transport resistance

Authors

C H Wang; A S Popel

Journal

Mathematical Biosciences

Year

1993

Species / model

In silico / modelling

Author institutions

Johns Hopkins University

Evidence type

Computational model

DOI

10.1016/0025-5564(93)90062-f

PMID

8343620

Original citation

C H Wang; A S Popel. Effect of red blood cell shape on oxygen transport in capillaries. Mathematical Biosciences. 1993;116(1):89-110. doi:10.1016/0025-5564(93)90062-f. PMID:8343620.

Research direction

Capillary oxygen transport models; RBC and extracellular hemoglobin comparisons; Facilitated diffusion and transport resistance

Authors

Iu Ia Kisliakov

Journal

Biofizika

Year

1996

Species / model

In silico / modelling

Evidence type

Computational model

PMID

8924469

Original citation

Iu Ia Kisliakov. [A mathematical model of O2 transport by erythrocytes in capillaries]. Biofizika. 1996;41(3):681-685. PMID:8924469.

Research direction

Capillary oxygen transport models; Facilitated diffusion and transport resistance

DOI not confirmed in the checked bibliographic sources; use the verified PubMed record.

Authors

Maithili Sharan; Aleksander S Popel

Journal

Journal of Theoretical Biology

Year

2002

Species / model

In silico / modelling

Author institutions

Indian Institute of Technology Delhi

Evidence type

Computational model

DOI

10.1006/jtbi.2002.3001

PMID

12151262

Original citation

Maithili Sharan; Aleksander S Popel. A compartmental model for oxygen transport in brain microcirculation in the presence of blood substitutes. Journal of Theoretical Biology. 2002;216(4):479-500. doi:10.1006/jtbi.2002.3001. PMID:12151262.

Research direction

Capillary oxygen transport models; Microcirculation, low hematocrit and tissue hypoxia; Oxygen distribution and vascular effects

Authors

Pedro Cabrales; Hiromi Sakai; Amy G Tsai; Shinji Takeoka; Eishun Tsuchida; Marcos Intaglietta

Journal

American Journal of Physiology Heart and Circulatory Physiology

Year

2005

Species / model

Rodent

Author institutions

University of California San Diego

Evidence type

Animal experimental study

DOI

10.1152/ajpheart.01004.2004

PMID

15563528

Original citation

Pedro Cabrales; Hiromi Sakai; Amy G Tsai; Shinji Takeoka; Eishun Tsuchida; Marcos Intaglietta. Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution. American Journal of Physiology Heart and Circulatory Physiology. 2005;288(4):H1885-H1892. doi:10.1152/ajpheart.01004.2004. PMID:15563528.

Research direction

P50, oxygen affinity and cooperativity; Microcirculation, low hematocrit and tissue hypoxia

Authors

Donald A Belcher; Alfredo Lucas; Pedro Cabrales; Andre F Palmer

Journal

Scientific Reports

Year

2020

Species / model

Rodent

Author institutions

The Ohio State University, University of California San Diego

Evidence type

Animal experimental study

DOI

10.1038/s41598-020-68190-0

PMID

32647211

Original citation

Donald A Belcher; Alfredo Lucas; Pedro Cabrales; Andre F Palmer. Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier. Scientific Reports. 2020;10(1):11372. doi:10.1038/s41598-020-68190-0. PMID:32647211.

Research direction

P50, oxygen affinity and cooperativity; Microcirculation, low hematocrit and tissue hypoxia; Oxygen distribution and vascular effects

Authors

Farhad A Amiri; Junfeng Zhang

Journal

Bulletin of Mathematical Biology

Year

2023

Species / model

In silico / modelling

Author institutions

Laurentian University

Evidence type

Computational model

DOI

10.1007/s11538-023-01155-2

PMID

37129671

Original citation

Farhad A Amiri; Junfeng Zhang. Tissue Oxygenation Around Capillaries: Effects of Hematocrit and Arteriole Oxygen Condition. Bulletin of Mathematical Biology. 2023;85(6):50. doi:10.1007/s11538-023-01155-2. PMID:37129671.

Research direction

Capillary oxygen transport models; Microcirculation, low hematocrit and tissue hypoxia

Authors

T C Page; W R Light; J D Hellums

Journal

Advances in Experimental Medicine and Biology

Year

1999

Species / model

In vitro / laboratory

Author institutions

Biopure Corporation

Evidence type

In vitro experimental study

PMID

10659206

Original citation

T C Page; W R Light; J D Hellums. Oxygen transport in 10 microns artificial capillaries. Advances in Experimental Medicine and Biology. 1999;471:715-721. PMID:10659206.

Research direction

RBC and extracellular hemoglobin comparisons; Facilitated diffusion and transport resistance

DOI not confirmed in the checked bibliographic sources; use the verified PubMed record.

Authors

Scott K Ferguson; Julie W Harral; David I Pak; Katherine M Redinius; Kurt R Stenmark; Dominik J Schaer; Paul W Buehler; David C Irwin

Journal

Nitric Oxide

Year

2018

Species / model

Rodent

Author institutions

U.S. Food and Drug Administration, University of Colorado, University of Zurich

Evidence type

Animal experimental study

DOI

10.1016/j.niox.2018.03.005

PMID

29526566

Original citation

Scott K Ferguson; Julie W Harral; David I Pak; Katherine M Redinius; Kurt R Stenmark; Dominik J Schaer; Paul W Buehler; David C Irwin. Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics. Nitric Oxide. 2018;76:29-36. doi:10.1016/j.niox.2018.03.005. PMID:29526566.

Research direction

Microcirculation, low hematocrit and tissue hypoxia; Oxygen distribution and vascular effects