BHOC · Biological Hemoglobin Oxygen Carrier

Precision Oxygen Therapeutics

A scientific intelligence platform connecting source-linked evidence, historical HBOC terminology and tissue-level oxygen delivery across veterinary medicine, transplantation and human-use research. Blood is a system. Oxygen delivery is a function.

Living Scientific Repository
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Human use · United StatesFDA Expanded AccessNot FDA approved · Open Human Use record →Human use · South AfricaFull clinical approvalApproved since 2001 · Open Human Use status →Human use · RussiaHistorical full approvalRegistered 2010-2015 · Open Human Use status →Veterinary approval · United StatesFDA Oxyglobin approvalNADA 141-067 · Open FDA veterinary record →Veterinary approval · European UnionEMA Oxyglobin approvalEU/2/99/015 · Open EMA veterinary record →Historical research · United StatesU.S. Navy RESUS research2003 NMRC agreement · Open source record →
474Publication & evidence recordsIndexed across three application hubs155Author institutions268 hub-level directory entries168Scientific journals218 hub-level journal entries141Animal-labelled recordsAcross 10 species and model categories

Evidence records are organised by application, so one publication may appear in more than one hub. Hub-level directory and journal entries include repeated labels across sections. Institutions are indexed author affiliations, not endorsements or automatically confirmed study locations.

Three application lenses · one evidence foundation

Explore the evidence in context.

Updated 27 Sep 2026

Veterinary

Oxyglobin regulatory history, animal and model evidence, species distribution, author institutions and original publication records.

236PUBLICATION RECORDS
10SPECIES / MODEL GROUPS
154AUTHOR INSTITUTIONS
109JOURNAL LABELS
Open Veterinary →

Transplantation

Liver, kidney, heart, limb and cross-organ evidence across preservation, machine perfusion, viability assessment and reperfusion.

53PUBLICATION RECORDS
5ORGAN DIRECTIONS
41AUTHOR INSTITUTIONS
13JOURNAL LABELS
Open Transplantation →

Human Use

Human clinical publications and separately labelled translational evidence across emergency care, severe anemia, surgery, cardiac ischemia and critical care.

185PUBLICATION RECORDS
6THERAPEUTIC DIRECTIONS
72AUTHOR INSTITUTIONS
96JOURNAL LABELS
Open Human Use →
Precision Oxygen Therapeutics

From oxygen in circulation to oxygen where it is needed.

Hemoglobin concentration and arterial saturation matter, but tissue oxygenation also depends on flow, microvascular distribution, diffusion, extraction and cellular utilisation. BHOC focuses on the oxygen-delivery function while recognising that blood performs many other essential functions.

01 / TRANSPORTOxygen loading and carriage
02 / DISTRIBUTIONPerfusion and microcirculation
03 / AVAILABILITYTissue exchange and utilisation
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Nobel medalScientific foundationsNobel Foundations of Oxygen, Metabolism & Physiology

Nobel-recognized discoveries that shaped modern understanding of oxygen delivery, metabolism, nitric oxide, hypoxia and oxygen sensing.

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The foundation and the future

Built on decades of work. Carried forward with purpose.

This platform stands on a vast scientific, clinical, regulatory and engineering foundation created by researchers, clinicians, institutions, regulators, manufacturing teams and development partners around the world. We recognise and thank every contributor who advanced this field at every stage of its evolution.

The core innovation team remains intact. In the hands of innovators, innovation does not stand still; it evolves, improves and moves forward.

BHOC and Precision Oxygen Therapeutics are presented as a scientific and technology-development approach. Historical product names and HBOC terminology are retained for evidence discovery. Publication inclusion does not establish regulatory approval, efficacy or a clinical recommendation.