Blood-loss anaemia
90% vs 45%
Oxyglobin 90% treatment success vs 45% control.
Veterinary evidence · Oxyglobin · HBOC-301
Oxyglobin / HBOC-301 — regulatory approval, clinical efficacy, oxygen delivery & scientific evidence.
Oxyglobin is hemoglobin glutamer-200 (bovine), developed as HBOC-301. This evidence page separates regulatory approval, clinical efficacy, direct comparison with packed red blood cells and oxygen-delivery research from any future BHOC formulation.
FDA pivotal efficacy
95% vs 32% treatment success in the efficacy population.
The original FDA field trial enrolled 64 client-owned anaemic dogs: 30 randomized to Oxyglobin and 34 to untreated control. Treatment success meant no additional oxygen-carrying support during the following 24 hours; it was not a survival endpoint.
Efficacy population: 20/21 (95%) Oxyglobin vs 9/28 (32%) control, p≤0.001. Intent-to-treat: 22/30 (73%) vs 10/34 (29%), p≤0.001.
EMA cause-stratified efficacy
100% treatment success in two evaluable anaemia strata.
The EMA scientific discussion reports treatment success by cause of anaemia using the same 24-hour efficacy concept: no additional oxygen-carrying support was required during the efficacy window.
Haemolytic anaemia
100% vs 9%
Oxyglobin 100% treatment success vs 9% control.
Ineffective erythropoiesis
100% vs 50%
Oxyglobin 100% treatment success vs 50% control.
How to read “100%”: all evaluable Oxyglobin-treated dogs in that cause-of-anaemia stratum met the 24-hour treatment-success endpoint. This is not a 100% survival or cure claim.
Open the detailed EMA / EU treatment-success evidence and source documents →
Prospective randomized clinical comparison · 2009
Oxyglobin vs packed red blood cells in canine babesiosis.
Zambelli AB, Leisewitz AL. Twelve dogs with naturally occurring Babesia rossi anaemia were randomized to Oxyglobin or packed red blood cell transfusion. The study reported similar overall improvements in blood-gas, acid-base and blood-pressure measures, while packed cells tended to normalize habitus and appetite more rapidly.
PMID 19691591 · DOI 10.1111/j.1476-4431.2009.00386.x
PubMed →Oxygen delivery · British Journal of Anaesthesia · 2001
Intestinal perfusion and oxygenation in canine hypovolaemia.
Driessen B, Jahr JS, Lurie F, Griffey SM, Gunther RA. This British Journal of Anaesthesia paper is a distinct full publication and is now retained separately from the related Veterinary Anaesthesia and Analgesia record.
PMID 11575346 · DOI 10.1093/bja/86.5.683
PubMed →Metadata correction · feline clinical evidence
44 hypotensive cats — JAVMA citation corrected.
Wehausen CE, Kirby R, Rudloff E. The prior journal label Hb-200 was incorrect. The verified source is the Journal of the American Veterinary Medical Association, 2011;238(7):909-914.
PMID 21453180 · DOI 10.2460/javma.238.7.909
PubMed →Historical feline Oxyglobin evidence · 2008
Clinical Oxyglobin use in 48 cats.
Weingart C, Kohn B. Retrospective report of 48 anaemic cats treated with Oxyglobin. Interpret adverse events and outcome only in the context of the studied product and clinical population; this is not BHOC-specific evidence.
PMID 18455461 · DOI 10.1016/j.jfms.2007.10.012
PubMed →Curation note
Similar titles are not automatically duplicate publications.
The British Journal of Anaesthesia paper PMID 11575346 and the related Veterinary Anaesthesia and Analgesia record PMID 28404246 are retained as separate records. The former must not replace the latter.
The historical parasite-induced anaemia record bhoc-056 remains in the bibliography but is explicitly marked SOURCE VERIFICATION REQUIRED until a sufficiently reliable primary PMID or DOI is established.
The live search applies these verified additions and corrections through the curated evidence layer while preserving the original 236-record bibliography snapshot for provenance.
01 / Search
Find the publication.
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Open publication search →02 / Base catalogue
Read the source bibliography.
Browse the preserved base catalogue with titles, authors, journals, PubMed records, DOI links and affiliations.
Open full catalogue →03 / Regulatory
Separate approval from literature.
FDA and EU / EMA records for Oxyglobin remain in the regulatory source library, including primary approval documents.
Open regulatory evidence →Evidence page updated 26 September 2026. The active publication search contains the preserved 236-record base bibliography plus three source-verified curated additions. Historical Oxyglobin evidence is not presented as regulatory evidence for a future BHOC formulation.