Oxygen loading and carriage
Hemoglobin binds and transports oxygen. The relevant properties depend on the specific molecular design, oxygen affinity and formulation.
The Technology
Biological Hemoglobin Oxygen Carrier technology.
BHOC describes a platform approach centered on hemoglobin-mediated oxygen transport outside the conventional red-cell framework. Scientific evaluation must remain technology-specific, indication-specific and evidence-specific.
BHOC
A functional oxygen-delivery platform.
BHOC means Biological Hemoglobin Oxygen Carrier. The term is used here to frame hemoglobin-mediated oxygen delivery around biological function rather than around the idea of replacing blood as a whole.
Blood performs many functions beyond oxygen transport. For that reason, BHOC Therapeutics does not position BHOC as “artificial blood” or as a replacement for donor blood.
Flow and microcirculation
Oxygen-carrying capacity has physiological meaning only when circulation and regional perfusion support delivery to tissue.
Tissue exchange and utilization
Effective delivery ultimately depends on unloading, diffusion, cellular oxygen sensing and metabolic demand.
Historical terminology
BHOC, HBOC and the evolution of the field.
Historical scientific literature commonly uses the term HBOC for hemoglobin-based oxygen carriers. Product names such as Oxyglobin and Hemopure are important to the scientific and regulatory history of the field. BHOC Therapeutics preserves these terms for evidence discovery while using Biological Hemoglobin Oxygen Carrier as its current platform terminology.
Evidence before claims
Technology statements should be traceable.
BHOC-platform contains the deeper scientific, veterinary, transplantation, human-use, historical and regulatory records used to place oxygen-carrier technologies in context.