Oxygen loading and carriage
Hemoglobin binds and transports oxygen. The relevant properties depend on the specific molecular design, oxygen affinity and formulation.
The Technology
Biological Hemoglobin Oxygen Carrier technology.
BHOC describes a platform approach centered on hemoglobin-mediated oxygen transport outside conventional red blood cells. Scientific evaluation must remain technology-specific, indication-specific and evidence-specific.
BHOC
A functional oxygen-delivery platform.
BHOC means Biological Hemoglobin Oxygen Carrier. The term is used here to frame hemoglobin-mediated oxygen delivery around biological function rather than around the idea of replacing blood as a whole.
Blood performs many functions beyond oxygen transport. For that reason, BHOC Therapeutics does not position BHOC as “artificial blood” or as a replacement for donor blood.
Flow and microcirculation
Oxygen-carrying capacity has physiological meaning only when circulation and regional perfusion support delivery to tissue.
Tissue exchange and utilization
Effective delivery ultimately depends on unloading, diffusion, cellular oxygen sensing and metabolic demand.
Historical terminology
BHOC, HBOC, Artificial Blood & Blood Substitute Terminology
Historical scientific literature commonly uses HBOC for hemoglobin-based oxygen carriers. Older literature and public discussion also use terms such as artificial blood and blood substitute. These terms remain useful for historical and search discovery, but they can imply replacement of the many functions of blood. Product names such as Oxyglobin and Hemopure (HBOC-201) are important to the scientific and regulatory history of the field.
BHOC Therapeutics keeps these legacy terms available for evidence discovery while using Biological Hemoglobin Oxygen Carrier and Precision Oxygen Therapeutics for current positioning.
BHOC - Biological Hemoglobin Oxygen Carrier: what is new, why we exist and terminology →
Evidence before claims
Technology statements should be traceable.
BHOC-platform contains the deeper scientific, veterinary, transplantation, human-use, historical and regulatory records used to place oxygen-carrier technologies in context.