Veterinary · clinical guidance
TRACS veterinary transfusion-safety evidence note added
Added a 20-point source-linked note on TRACS Part 2, with a separate BHOC research question and a short Veterinary News announcement.
Latest BHOC Knowledge Updates
What changed recently.
The three most recent significant additions to the BHOC knowledge base. The full chronological record is preserved in the Knowledge Updates timeline.
Publication · Hemoglobin dose
Hemoglobin Dose and Red Cell Transfusion preprint published
New narrative review by Carl W. Rausch and Archil Jaliashvili examines component variability, oxygen function and measurement uncertainty. The news includes the publication record and acknowledgments of seven contributing colleagues.
Emergency medicine · News
Hemorrhage Control and Tissue Oxygenation
Published a concise news perspective on the University of Colorado Anschutz DARPA RAPIID award, connecting hemorrhage control, tissue oxygenation, small-volume oxygen support and research on tourniquet-associated ischemia.
A
Context & Purpose
Understand the field. Then the BHOC question.
What is BHOC?
Definition, scope and the oxygen-delivery function.
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Historical Evolution
From bloodletting and transfusion to oxygen therapeutics.
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Artificial Blood, Blood Substitute & HBOC Terminology
Historical language, expectations and the marketing trap.
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Historical Misinterpretation of the HBOC Class Effect
A separate critical review of historical class-wide conclusions.
Natanson review · separate reserved chapter
Why BHOC?
From replacing a whole system to supporting a defined function.
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B
The Biological System
From hemoglobin to tissue oxygen availability.
Nobel Foundations
Oxygen, metabolism and physiology: the connected scientific foundations.
Open the existing resource ↗
How Nature Controls Oxygen Delivery
Four levels of one connected system. Go straight to the complete chapter.
Evolution & Biological Adaptation
The oxygen-binding core and the biological systems built around it.
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Human Variation
Hemoglobin variants, population genetics and blood-group systems remain distinct layers of human biology.
Detailed chapter not yet available
Animal Variation
Species-specific hemoglobin biology, blood groups and oxygen-delivery adaptation will be developed within BHOC Veterinary.
Open BHOC Veterinary ↗
C
From Biology to BHOC
What changes outside the cell, and why it matters.
What Changes Outside the RBC?
The same oxygen-binding core, operating in a different architecture.
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Vascular Control & Vasoconstriction
Scientific evidence and an author-generated research hypothesis.
What Makes BHOC Different?
Biology, function, technology, physiology, evidence and application.
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D
Purpose & Evidence
Connect the approach to the source material.
Why We Exist
Precision Oxygen Therapeutics. Why BHOC exists.
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Evidence, Applications & Research Resources
Find the source library, specialist hub or research concept.
Who is developing BHOC?
BHOC Therapeutics · Archil Jaliashvili
Author & organisation